Tubeimoside I/Ⅱ/Ⅲ powder Bolbostemma paniculatum

How can get Tubeimoside I/Ⅱ/Ⅲ powder?

Bolbostemma paniculatum (Maxim.) Franquet. The source is the dried tuber of the cucurbitaceous Fritillary. Pick in autumn, wash, break, boil until no white heart, remove, dry. They are irregular blocks, varying in size. The surface is light reddish brown or dark brown, uneven. Hard, not easy to break, cutin section, bright and smooth.

Fritillary is a kind of traditional Chinese medicine. Tubeimoside I and TubeiMoside II are both antitumor active ingredients isolated and purified from Fritillaria Tubeimoside, belonging to oleane-type triterpene saponins. The only difference between Tubeimoside I and TubeiMoside II in structure is Tubeimoside The hydroxyl group on the II16 carbon. The structure-activity relationship between Tubeimoside I and TubeiMoside II showed that the antitumor activity of TubeiMoside II was stronger and less toxic than that of Tubeimoside I. Both Tubeimoside I and TubeiMoside II can induce cell cycle arrest and apoptosis.

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